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Article

Structural basis for the DNA-binding activity of human ARID4B Tudor domain

1 Jan 2021

Abstract excerpt

Human ARID4A and ARID4B are homologous proteins that are important in controlling gene expression and epigenetic regulation but have distinct functions. Previous studies have shown that the N-terminal domain of ARID4A is an unusual interdigitated double Tudor domain with DNA-binding activity. However, how the Tudor domain of ARID4B differs from that of ARID4A remains unknown. Here, we found that the ARID4B Tudor...

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PMID: 33675746
DOI: 10.1016/j.jbc.2021.100506

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