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Article

Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism

14 May 2018

Abstract excerpt

Abstract Circadian rhythms coordinate an organism’s activities and biological processes to the optimal time in the 24-h daylight cycle. We previously demonstrated that male C57BL/6 mice develop sepsis more rapidly when the disease is induced in the nighttime versus the daytime. In this report, we elucidate the mechanism of this diurnal difference. Sepsis was induced via cecal ligation and puncture (CLP) at...

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Identifiers

PMID: 29760192
DOI: 10.4049/jimmunol.1701677

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