Article
Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy.
Cell death & disease - 10 Jul 2018
Lin Xin, Cui Ming, Xu Dong, Hong Dubeiqi, Xia Yan, Xu Chentong, Li Riyong, Zhang Xuan, Lou Yaxin, He Qihua, Lv Ping, Chen Yingyu
Abstract excerpt
Acute liver failure (ALF) is an inflammation-mediated hepatocellular injury process associated with cellular autophagy. However, the mechanism by which autophagy regulates ALF remains undefined. Herein, we demonstrated that Eva1a (eva-1 homolog A)/Tmem166 (transmembrane protein 166), an autophagy-related gene, can protect mice from ALF induced by D-galactosamine (D-GalN)/lipopolysaccharide (LPS) via autophagy....
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