Article
In Vivo Intradermal Delivery of Bacteria by Using Microneedle Arrays.
Infection and immunity - 1 Sept 2018
Chandler Courtney E, Harberts Erin M, Laemmermann Tim, Zeng Qin, Opene Belita N, Germain Ronald N, Jewell Christopher M, Scott Alison J, Ernst Robert K
Abstract excerpt
Infectious diseases propagated by arthropod vectors, such as tularemia, are commonly initiated via dermal infection of the skin. However, due to the technical difficulties in achieving accurate and reproducible dermal deposition, intradermal models are less commonly used. To overcome these limitations, we used microneedle arrays (MNAs), which are micron-scale polymeric structures, to temporarily disrupt the...
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