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Article

Topical imiquimod yields systemic effects due to unintended oral uptake.

Scientific reports - 28 Jan 2016

Grine Lynda, Steeland Sophie, Van Ryckeghem Sara, Ballegeer Marlies, Lienenklaus Stefan, Weiss Siegfried, Sanders Niek N, Vandenbroucke Roosmarijn E, Libert Claude

Abstract excerpt

Repetitive application of topical imiquimod is used as an experimental model for the induction of psoriasiform skin lesions in mice. The model is characterized by several inflammatory processes, including cytokine production both locally and systemically, cellular infiltration, and splenomegaly. To investigate the production of type I interferons in response to imiquimod-containing Aldara cream, IFNβ-luciferase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26818707
DOI: 10.1038/srep20134
PMCID: PMC4730190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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