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Article

A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis

9 Jul 2018

Abstract excerpt

BACKGROUND: Idiopathic pulmonary fibrosis is a fatal lung disease characterized by a progressive formation of fibroblastic foci in the interstitium. This disease is strongly associated with telomere dysfunction but the extent of telomere shortening and consequent chromosomal damage within IPF lungs and with regional disease severity remains unknown. METHODS: Explanted IPF lungs (n = 10) were collected from...

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PMID: 29986708
DOI: 10.1186/s12931-018-0838-4

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