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Article

Successful Treatment with a High-dose Rifampin-containing Regimen for Pulmonary Tuberculosis with a Disputed rpoB Mutation.

Internal medicine (Tokyo, Japan) - 15 Nov 2018

Jeong Dae Hyun, Kang Ye Won, Kim Jin Young, Han Ji Soo, Jo Kyung-Wook, Shim Tae Sun

Abstract excerpt

Mutations in the rpoB gene of Mycobacterium tuberculosis can result in resistance to rifampin. Among various mutations in the rpoB gene, some known as disputed rpoB mutations can cause low-level rifampin resistance. It has been suggested that a high-dose rifampin (20 mg/kg)-based regimen might be effective in treating tuberculosis (TB) caused by M. tuberculosis with disputed rpoB mutations exhibiting low-level...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Drug

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Source

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Identifiers

PMID: 29984742
DOI: 10.2169/internalmedicine.9571-17
PMCID: PMC6288001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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