Article
A deletion in the golgi alpha-mannosidase II gene of Caenorhabditis elegans results in unexpected non-wild-type N-glycan structures.
The Journal of biological chemistry - 22 Sept 2006
Paschinger Katharina, Hackl Matthias, Gutternigg Martin, Kretschmer-Lubich Dorothea, Stemmer Ute, Jantsch Verena, Lochnit Günter, Wilson Iain B H
Abstract excerpt
The processing of N-linked oligosaccharides by alpha-mannosidases in the endoplasmic reticulum and Golgi is a process conserved in plants and animals. After the transfer of a GlcNAc residue to Asn-bound Man(5)GlcNAc(2) by N-acetylglucosaminyltransferase I, an alpha-mannosidase (EC 3.2.1.114) removes one alpha1,3-linked and one alpha1,6-linked mannose residue. In this study, we have identified the relevant...
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