Article
Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer's disease.
Menopause (New York, N.Y.) - 1 Jan 2019
Karim Roksana, Koc Melissa, Rettberg Jamaica R, Hodis Howard N, Henderson Victor W, St John Jan A, Allayee Hooman, Brinton Roberta D, Mack Wendy J
Abstract excerpt
OBJECTIVE: We hypothesized the association of metabolic profile on cognition in postmenopausal women will be greater among ApoE4 carriers compared with noncarriers. METHODS: Metabolic biomarkers and measures of global cognition, executive functions, and verbal memory, collected among postmenopausal females, were used in this analysis. Clustering analyses of metabolic biomarkers revealed three phenotypes: healthy,...
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