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Article

AUDIT-C and ICD codes as phenotypes for harmful alcohol use: association with ADH1B polymorphisms in two US populations.

Addiction (Abingdon, England) - 1 Dec 2018

Justice Amy C, Smith Rachel V, Tate Janet P, McGinnis Kathleen, Xu Ke, Becker William C, Lee Kuang-Yao, Lynch Kevin, Sun Ning, Concato John, Fiellin David A, Zhao Hongyu, Gelernter Joel, Kranzler Henry R

Abstract excerpt

BACKGROUND AND AIMS: Longitudinal electronic health record (EHR) data offer a large-scale, untapped source of phenotypical information on harmful alcohol use. Using established, alcohol-associated variants in the gene that encodes the enzyme alcohol dehydrogenase 1B (ADH1B) as criterion standards, we compared the individual and combined validity of three longitudinal EHR-based phenotypes of harmful alcohol use:...

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PMID: 29972609
DOI: 10.1111/add.14374
PMCID: PMC6226338

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MAF
MVP

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