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Article

Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B.

Alcoholism, clinical and experimental research - 1 May 2017

Justice Amy C, McGinnis Kathleen A, Tate Janet P, Xu Ke, Becker William C, Zhao Hongyu, Gelernter Joel, Kranzler Henry R

Abstract excerpt

BACKGROUND: Although alcohol risk is heritable, few genetic risk variants have been identified. Longitudinal electronic health record (EHR) data offer a largely untapped source of phenotypic information for genetic studies, but EHR-derived phenotypes for harmful alcohol exposure have yet to be validated. Using a variant of known effect, we used EHR data to develop and validate a phenotype for harmful alcohol...

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Identifiers

PMID: 28295416
DOI: 10.1111/acer.13373
PMCID: PMC5501250

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