Article
Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2024
Thorpe Hayley H A, Fontanillas Pierre, Pham Benjamin K, Meredith John J, Jennings Mariela V, Courchesne-Krak Natasia S, Vilar-Ribó Laura, Bianchi Sevim B, Mutz Julian, Elson Sarah L, Khokhar Jibran Y, Abdellaoui Abdel, Davis Lea K, Palmer Abraham A, Sanchez-Roige Sandra
Abstract excerpt
Coffee is one of the most widely consumed beverages. We performed a genome-wide association study (GWAS) of coffee intake in US-based 23andMe participants (N = 130,153) and identified 7 significant loci, with many replicating in three multi-ancestral cohorts. We examined genetic correlations and performed a phenome-wide association study across hundreds of biomarkers, health, and lifestyle traits, then compared...
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