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Article

Association of ABCC2 polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients.

Lung cancer (Amsterdam, Netherlands) - 1 May 2011

Han Baohui, Gao Ge, Wu Wenting, Gao Zhiqiang, Zhao Xueying, Li Ling, Qiao Rong, Chen Hongyan, Wei Qingyi, Wu Jinchang, Lu Daru

Abstract excerpt

Platinum-based chemotherapy is the most common treatment for non-small cell lung cancer (NSCLC), and expression levels of drug metabolism and transport proteins are correlated with its efficacy and toxicity. In this study, we investigated the association of three putative functional polymorphisms of ABCC2 (C-24T, G1249A, and C3972T) with tumor response and occurrence of the grade 3 or 4 toxicity in 445 patients...

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Source

Identifiers

PMID: 20943283
DOI: 10.1016/j.lungcan.2010.09.001

Genes

ABCC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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