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Article

Photodynamic activity of Temoporfin nanoparticles induces a shift to the M1-like phenotype in M2-polarized macrophages.

Journal of photochemistry and photobiology. B, Biology - 1 Aug 2018

Zhu Zhenxin, Scalfi-Happ Claudia, Ryabova Anastasia, Gräfe Susanna, Wiehe Arno, Peter Ralf-Uwe, Loschenov Victor, Steiner Rudolf, Wittig Rainer

Abstract excerpt

The monocyte/macrophage cell lineage reveals an enormous plasticity, which is required for tissue homeostasis, but is also undermined in various disease states, leading to a functional involvement of macrophages in major human diseases such as atherosclerosis and cancer. We recently generated in vivo evidence that crystalline, nonfluorescent nanoparticles of the hydrophobic porphyrin-related photosensitizer...

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Identifiers

PMID: 29966988
DOI: 10.1016/j.jphotobiol.2018.06.015

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