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Article

Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis.

European journal of human genetics : EJHG - 1 Oct 2018

Abstract excerpt

The most recent genome-wide association study in amyotrophic lateral sclerosis (ALS) demonstrates a disproportionate contribution from low-frequency variants to genetic susceptibility to disease. We have therefore begun Project MinE, an international collaboration that seeks to analyze whole-genome sequence data of at least 15 000 ALS patients and 7500 controls. Here, we report on the design of Project MinE and...

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Identifiers

PMID: 29955173
DOI: 10.1038/s41431-018-0177-4
PMCID: PMC6138692

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