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Article

Driver gene mutations based clustering of tumors: methods and applications.

Bioinformatics (Oxford, England) - 1 Jul 2018

Zhang Wensheng, Flemington Erik K, Zhang Kun

Abstract excerpt

Motivation: Somatic mutations in proto-oncogenes and tumor suppressor genes constitute a major category of causal genetic abnormalities in tumor cells. The mutation spectra of thousands of tumors have been generated by The Cancer Genome Atlas (TCGA) and other whole genome (exome) sequencing projects. A promising approach to utilizing these resources for precision medicine is to identify genetic similarity-based...

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PMID: 29950003
DOI: 10.1093/bioinformatics/bty232
PMCID: PMC6022677

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