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Article

Efficient computation of the joint probability of multiple inherited risk alleles from pedigree data.

Genetic epidemiology - 1 Sept 2018

Madsen Thomas, Braun Danielle, Peng Gang, Parmigiani Giovanni, Trippa Lorenzo

Abstract excerpt

The Elston-Stewart peeling algorithm enables estimation of an individual's probability of harboring germline risk alleles based on pedigree data, and serves as the computational backbone of important genetic counseling tools. However, it remains limited to the analysis of risk alleles at a small number of genetic loci because its computing time grows exponentially with the number of loci considered. We propose a...

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Identifiers

PMID: 29943416
DOI: 10.1002/gepi.22130
PMCID: PMC6129424

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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