Article
Eosinophilic Solid and Cystic (ESC) Renal Cell Carcinomas Harbor TSC Mutations: Molecular Analysis Supports an Expanding Clinicopathologic Spectrum.
The American journal of surgical pathology - 1 Sept 2018
Palsgrove Doreen N, Li Yunjie, Pratilas Christine A, Lin Ming-Tseh, Pallavajjalla Aparna, Gocke Christopher, De Marzo Angelo M, Matoso Andres, Netto George J, Epstein Jonathan I, Argani Pedram
Abstract excerpt
Eosinophilic solid and cystic (ESC) renal cell carcinoma (RCC) has recently been described as a potentially new subtype of RCC based upon morphologic and immunohistochemical features. These neoplasms typically demonstrate solid and cystic architecture, and the neoplastic cells contain voluminous eosinophilic cytoplasm with granular cytoplasmic stippling. There is frequently focal immunoreactivity for cytokeratin...
Topics
- Adolescent
- Adult
- Aged
- Biomarkers, Tumor
- Carcinoma, Renal Cell
- Eosinophilia
- Female
- Humans
- Kidney Neoplasms
- Male
- Middle Aged
- Mutation
- Tuberous Sclerosis Complex 1 Protein