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Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios

25 Jun 2018

Abstract excerpt

BACKGROUND: The adaptive immune response intrinsically depends on hypervariable human leukocyte antigen (HLA) genes. Concomitantly, correct HLA phenotyping is crucial for successful donor-patient matching in organ transplantation. The cost and technical limitations of current laboratory techniques, together with advances in next-generation sequencing (NGS) methodologies, have increased the need for precise...

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PMID: 29940840
DOI: 10.1186/s12859-018-2239-6

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