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Article

Extracellular matrix surface regulates self-assembly of three-dimensional placental trophoblast spheroids

25 Jun 2018

Abstract excerpt

The incorporation of the extracellular matrix (ECM) is essential for generating in vitro models that truly represent the microarchitecture found in human tissues. However, the cell-cell and cell-ECM interactions in vitro remains poorly understood in placental trophoblast biology. We investigated the effects of varying the surface properties (surface thickness and stiffness) of two ECMs, collagen I and Matrigel,...

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PMID: 29940046
DOI: 10.1371/journal.pone.0199632

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