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Disease-specific extracellular matrix composition regulates placental trophoblast fusion efficiency

1 Jan 2021

Abstract excerpt

The placental syncytiotrophoblast is a multinucleated layer that regulates transport between the mother and fetus. Fusion of trophoblasts is essential to form this layer, but this process can be disrupted in pregnancy-related disorders such as preeclampsia. Disease progression is also associated with changes in the extracellular matrix (ECM), but whether disease-specific ECM compositions play any causal role in...

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PMID: 34608901
DOI: 10.1039/d1bm00799h

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