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Article

A Novel Three‐Dimensional <i>In Vitro</i> System to Study Trophoblast–Endothelium Cell Interactions

22 Jun 2007

Abstract excerpt

INTRODUCTION: Pregnancy complications have been linked to improper trophoblast migration and failure of spiral artery transformation. Endothelial cells play an essential role in directing trophoblast migration and transformation, although by an unknown mechanism. We describe a novel in vitro model to evaluate endothelial-trophoblast interaction and signaling in a three-dimensional system. METHOD OF STUDY:...

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PMID: 17631003
DOI: 10.1111/j.1600-0897.2007.00493.x

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