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Article

Mitotic defects in fission yeast lipid metabolism 'cut' mutants are suppressed by ammonium chloride.

FEMS yeast research - 1 Sept 2018

Zach Róbert, Tvaružková Jarmila, Schätz Martin, Tupa Ondrej, Grallert Beáta, Prevorovský Martin

Abstract excerpt

Fission yeast 'cut' mutants show defects in temporal coordination of nuclear division with cytokinesis, resulting in aberrant mitosis and lethality. Among other causes, the 'cut' phenotype can be triggered by genetic or chemical perturbation of lipid metabolism, supposedly resulting in shortage of membrane phospholipids and insufficient nuclear envelope expansion during anaphase. Interestingly, penetrance of the...

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Identifiers

PMID: 29931271
DOI: 10.1093/femsyr/foy064
PMCID: PMC6037054

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