Article
Analysis of Serum Interleukin (IL)-1β and IL-18 in Systemic Lupus Erythematosus.
Frontiers in immunology - 1 Jan 2018
Mende Rachel, Vincent Fabien B, Kandane-Rathnayake Rangi, Koelmeyer Rachel, Lin Emily, Chang Janet, Hoi Alberta Y, Morand Eric F, Harris James, Lang Tali
Abstract excerpt
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by biological and clinical heterogeneity. The interleukin (IL)-1 superfamily is a group of innate cytokines that contribute to pathogenesis in many autoimmune diseases. IL-1β and IL-18 are two members that have been shown to play a role in murine lupus-like models, but their role in human SLE remains poorly understood....
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