Article
CD4:8 ratio >5 is associated with a dominant naive T-cell phenotype and impaired physical functioning in CMV-seropositive very elderly people: results from the BELFRAIL study.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Feb 2015
Adriaensen Wim, Derhovanessian Evelyna, Vaes Bert, Van Pottelbergh Gijs, Degryse Jean-Marie, Pawelec Graham, Hamprecht Klaus, Theeten Heidi, Matheï Catharina
Abstract excerpt
A subset of older people is at increased risk of hospitalization and dependency. Emerging evidence suggests that immunosenescence reflected by an inverted CD4:8 ratio and cytomegalovirus (CMV) seropositivity plays an important role in the pathophysiology of functional decline. Nevertheless, the r...
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