Article
Detection of genetic cardiac diseases by Ca2+ transient profiles using machine learning methods.
Scientific reports - 19 Jun 2018
Juhola Martti, Joutsijoki Henry, Penttinen Kirsi, Aalto-Setälä Katriina
Abstract excerpt
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have revolutionized cardiovascular research. Abnormalities in Ca2+ transients have been evident in many cardiac disease models. We have shown earlier that, by exploiting computational machine learning methods, normal Ca2+ transients corresponding to healthy CMs can be distinguished from diseased CMs with abnormal transients. Here our aim was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.