Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancer

9 May 2023

Abstract excerpt

Abstract Vimentin is highly expressed in metastatic cancers, and its expression correlates with poor patient prognoses. However, no causal in vivo studies linking vimentin and non–small cell lung cancer (NSCLC) progression existed until now. We use three complementary in vivo models to show that vimentin is required for the progression of NSCLC. First, we crossed LSL-Kras G12D ; Tp53 fl/fl mice ( KPV +/+ ) with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Ferroptosis and cancer prognosis
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37161053
DOI: 10.1038/s41388-023-02703-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancerPMID 37161053Read ↗

Pathophysiological Role of Vimentin Intermediate Filaments in Lung DiseasesSemantic proximity Read ↗

The hsa-miR-520a/MYO19 Axis Modulates Tumor Progression and Immune Evasion Through Ferroptosis in Lung Squamous Cell Carcinoma: Insights from Pan-Cancer AnalysisSemantic proximity Read ↗

Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated MetastasisSemantic proximity Read ↗

Aging promotes lung cancer metastasis through epigenetic ATF4 inductionSemantic proximity Read ↗

Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancerSemantic proximity Read ↗

FMO4 drives lung adenocarcinoma by stabilizing the MAT2A/MAT2B complex and hindering ferroptosisSemantic proximity Read ↗

U2AF65 mediated circPVT1 promotes NSCLC cell proliferation and inhibits ferroptosis through the miR-338-3p/GPX4 axisSemantic proximity Read ↗

Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2.Semantic proximity Read ↗

FRK plays an oncogenic role in non‐small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogrammingSemantic proximity Read ↗

Transfer of Damaged Mitochondria from Cancer Cells to Cancer-Associated Fibroblasts Promotes Tyrosine Kinase Inhibitor Tolerance in EGFR-Mutant Lung Cancer.Semantic proximity Read ↗

Intermediate filaments of the lung.Semantic proximity Read ↗

Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.