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Article

Synonymous nucleotide modification of the KCNH2 gene affects both mRNA characteristics and translation of the encoded hERG ion channel

18 Jun 2018

Abstract excerpt

Synonymous nucleotide variation is increasingly recognized as a factor than can affect protein expression, but the underlying mechanisms are incompletely understood. Here, we investigated whether synonymous changes could affect expression of the potassium voltage-gated channel subfamily H member 2 ( KCNH2 ) gene, encoding the human ether-a-go-go–related gene (hERG) ion channel, which is linked to hereditary...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 29907571
DOI: 10.1074/jbc.ra118.001805

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