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Article

Sequence and structure-specific elements of HERG mRNA determine channel synthesis and trafficking efficiency.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2013

Sroubek Jakub, Krishnan Yamini, McDonald Thomas V

Abstract excerpt

Human ether-á-gogo-related gene (HERG) encodes a potassium channel that is highly susceptible to deleterious mutations resulting in susceptibility to fatal cardiac arrhythmias. Most mutations adversely affect HERG channel assembly and trafficking. Why the channel is so vulnerable to missense mutations is not well understood. Since nothing is known of how mRNA structural elements factor in channel processing, we...

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Source

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Identifiers

PMID: 23608144
DOI: 10.1096/fj.12-227009
PMCID: PMC3714577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sequence and structure-specific elements of HERG mRNA determine channel synthesis and trafficking efficiency.PMID 23608144Read ↗

Synonymous nucleotide modification of the KCNH2 gene affects both mRNA characteristics and translation of the encoded hERG ion channelSemantic proximity Read ↗

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A K+ Channel Splice Variant Common in Human Heart Lacks a C-terminal Domain Required for Expression of Rapidly Activating Delayed Rectifier CurrentSemantic proximity Read ↗

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