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CDKN2A inhibits formation of homotypic cell-in-cell structures

5 Jun 2018

Abstract excerpt

Cell-in-cell (CIC) structures, characterized by enclosure of one or more cells within another cell, were extensively documented in human cancers. Although elevated CIC formation was found in cancers with CDKN2A inactivation, a causal link between them remains to be established. We reported here that inhibiting CDKN2A expression effectively promoted homotypic CIC formation, whereas ectopic overexpression of...

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PMID: 29904067
DOI: 10.1038/s41389-018-0056-4

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