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Article

Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells.

Journal of experimental & clinical cancer research : CR - 11 May 2020

Liu Kai, Zheng Minying, Zhao Qi, Zhang Kexin, Li Zugui, Fu Fangmei, Zhang Hao, Du Jiaxing, Li Yuwei, Zhang Shiwu

Abstract excerpt

BACKGROUND: Our previous studies have confirmed that cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells (PGCCs), which is the key to the heterogeneity of solid tumors. PGCC formation is closely related to the abnormal expression of cell cycle-related proteins and cell fusion. In this study, we investigated the molecular mechanism of PGCCs formation by detecting the expression of cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32393310
DOI: 10.1186/s13046-020-01588-w
PMCID: PMC7212590

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