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Article

Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes.

European journal of human genetics : EJHG - 1 Oct 2018

Chiquet Brett T, Yuan Qiuping, Swindell Eric C, Maili Lorena, Plant Robert, Dyke Jeffrey, Boyer Ryan, Teichgraeber John F, Greives Matthew R, Mulliken John B, Letra Ariadne, Blanton Susan H, Hecht Jacqueline T

Abstract excerpt

Orofacial development is a multifaceted process involving tightly regulated genetic signaling networks, that when perturbed, lead to orofacial abnormalities including cleft lip and/or cleft palate. We and others have shown an association between the cysteine-rich secretory protein LCCL domain containing 2 (CRISPLD2) gene and nonsyndromic cleft lip with or without cleft palate (NSCLP). Further, we demonstrated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gene Expression Regulation, Developmental

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Source

Open in PubMed Open full text

Identifiers

PMID: 29899370
DOI: 10.1038/s41431-018-0192-5
PMCID: PMC6138754

Genes

FOS
MMP2
CASP8
CRISPLD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes.PMID 29899370Read ↗

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