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Integrating GWAS and eQTL to predict genes and pathways for non-syndromic cleft lip with or without palate.

Oral diseases - 1 Oct 2021

Yang Jing, Yu Xin, Zhu Guirong, Wang Ruimin, Lou Shu, Zhu Weihao, Fu Chengyi, Liu Jinsuo, Fan Liwen, Li Dandan, Shao Qinghua, Ma Lan, Wang Lin, Wang Zhendong, Pan Yongchu

Abstract excerpt

OBJECTIVE: To explore susceptibility genes and pathways for non-syndromic cleft lip with or without cleft palate (NSCL/P). MATERIALS AND METHODS: Two genome-wide association studies (GWAS) datasets, including 858 NSCL/P cases and 1,248 controls, were integrated with expression quantitative trait loci (eQTL) dataset identified by Genotype-Tissue Expression (GTEx) project in whole-blood samples. The expression of...

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PMID: 33128317
DOI: 10.1111/odi.13699

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