Article
Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection.
Birth defects research. Part A, Clinical and molecular teratology - 1 Jan 2011
Chiquet Brett T, Henry Robin, Burt Amber, Mulliken John B, Stal Samuel, Blanton Susan H, Hecht Jacqueline T
Abstract excerpt
BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common birth defect that has a multifactorial etiology. Despite having substantial genetic liability, <15% of the genetic contribution to NSCLP has been delineated. In our efforts to dissect the genetics of NSCLP, we found that variation in the CRISPLD2 (cysteine-rich secretory protein LCCL domain containing 2) gene is associated with...
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