Article
An InDel in Phospholipase-C-B-1 Is Linked with Euthyroid Multinodular Goiter.
Thyroid : official journal of the American Thyroid Association - 1 Jul 2018
Bakhsh Ameen D, Ladas Ioannis, Hamshere Marian L, Bullock Martyn, Kirov George, Zhang Lei, Taylor Peter N, Gregory John W, Scott-Coombes David, Völzke Henry, Teumer Alexander, Mantripragada Kiran, Williams E Dillwyn, Clifton-Bligh Roderick J, Williams Nigel M, Ludgate Marian E
Abstract excerpt
BACKGROUND: Euthyroid multinodular goiter (MNG) is common, but little is known about the genetic variations conferring predisposition. Previously, a family with MNG of adolescent onset was reported in which some family members developed papillary thyroid carcinomas (PTC). METHODS: Genome-wide linkage analysis and next-generation sequencing were conducted to identify genetic variants that may confer disease...
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