Integrated Genomic Classification of Melanocytic Tumors of the Central Nervous System Using Mutation Analysis, Copy Number Alterations, and DNA Methylation Profiling.

doi:10.1158/1078-0432.CCR-18-0763

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Article

Integrated Genomic Classification of Melanocytic Tumors of the Central Nervous System Using Mutation Analysis, Copy Number Alterations, and DNA Methylation Profiling.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2018

Griewank Klaus G, Koelsche Christian, van de Nes Johannes A P, Schrimpf Daniel, Gessi Marco, Möller Inga, Sucker Antje, Scolyer Richard A, Buckland Michael E, Murali Rajmohan, Pietsch Torsten, von Deimling Andreas, Schadendorf Dirk

Abstract excerpt

Purpose: In the central nervous system, distinguishing primary leptomeningeal melanocytic tumors from melanoma metastases and predicting their biological behavior solely using histopathologic criteria may be challenging. We aimed to assess the diagnostic and prognostic value of integrated molecular analysis.Experimental Design: Targeted next-generation sequencing, array-based genome-wide methylation analysis, and...

Topics

Adult
Aged
Aged, 80 and over
Central Nervous System Neoplasms
Chromosomes, Human, Pair 3
DNA Copy Number Variations
DNA Methylation
DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genomics

Humans

Male

Melanoma

Middle Aged

Mutation

Neoplasm Metastasis

Nevus, Blue

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 29891723
DOI: 10.1158/1078-0432.CCR-18-0763

Genes

BAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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