Article
Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles.
Brain pathology (Zurich, Switzerland) - 1 Mar 2015
Koelsche Christian, Hovestadt Volker, Jones David T W, Capper David, Sturm Dominik, Sahm Felix, Schrimpf Daniel, Adeberg Sebastian, Böhmer Katja, Hagenlocher Christian, Mechtersheimer Gunhild, Kohlhof Patricia, Mühleisen Helmut, Beschorner Rudi, Hartmann Christian, Braczynski Anne Kristin, Mittelbronn Michel, Buslei Rolf, Becker Albert, Grote Alexander, Urbach Horst, Staszewski Ori, Prinz Marco, Hewer Ekkehard, Pfister Stefan M, von Deimling Andreas, Reuss David E
Abstract excerpt
Melanotic tumors of the nervous system show overlapping histological characteristics but differ substantially in their biological behavior. In order to achieve a better delineation of such tumors, we performed an in-depth molecular characterization. Eighteen melanocytomas, 12 melanomas, and 14 melanotic and 14 conventional schwannomas (control group) were investigated for methylome patterns (450k array), gene...
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