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Article

Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells.

The Journal of clinical investigation - 2 Jul 2018

Weniger Marc A, Tiacci Enrico, Schneider Stefanie, Arnolds Judith, Rüschenbaum Sabrina, Duppach Janine, Seifert Marc, Döring Claudia, Hansmann Martin-Leo, Küppers Ralf

Abstract excerpt

Very few B cells in germinal centers (GCs) and extrafollicular (EF) regions of lymph nodes express CD30. Their specific features and relationship to CD30-expressing Hodgkin and Reed/Sternberg (HRS) cells of Hodgkin lymphoma are unclear but highly relevant, because numerous patients with lymphoma are currently treated with an anti-CD30 immunotoxin. We performed a comprehensive analysis of human CD30+ B cells....

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Share to Genes, Immunoglobulin Heavy Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Hodgkin Disease

Share to Immunoglobulin Class Switching

Share to Ki-1 Antigen

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Share to Tumor Necrosis Factor Receptor Superfamily, Member 7

Source

Open in PubMed Open full text

Identifiers

PMID: 29889102
DOI: 10.1172/JCI95993
PMCID: PMC6025985

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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