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Article

Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30)

8 Sept 2004

Abstract excerpt

Animal models are essential for elucidating the molecular mechanisms of carcinogenesis. Hodgkin's and many diverse non-Hodgkin's lymphomas overexpress the Hodgkin's disease antigen CD30 (CD30(hi)), a tumor necrosis factor receptor II family member. Here we show that chicken Marek's disease (MD) lymphoma cells are also CD30(hi) and are a unique natural model for CD30(hi) lymphoma. Chicken CD30 resembles an...

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PMID: 15356338
DOI: 10.1073/pnas.0305789101

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