Article
Combined SOM-portrayal of gene expression and DNA methylation landscapes disentangles modes of epigenetic regulation in glioblastoma.
Epigenomics - 1 Jun 2018
Hopp Lydia, Löffler-Wirth Henry, Galle Jörg, Binder Hans
Abstract excerpt
AIM: We present here a novel method that enables unraveling the interplay between gene expression and DNA methylation in complex diseases such as cancer. MATERIALS & METHODS: The method is based on self-organizing maps and allows for analysis of data landscapes from 'governed by methylation' to 'governed by expression'. RESULTS: We identified regulatory modules of coexpressed and comethylated genes in high-grade...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.