Article
Long-read whole genome sequencing and comparative analysis of six strains of the human pathogen Orientia tsutsugamushi.
PLoS neglected tropical diseases - 1 Jun 2018
Batty Elizabeth M, Chaemchuen Suwittra, Blacksell Stuart, Richards Allen L, Paris Daniel, Bowden Rory, Chan Caroline, Lachumanan Ramkumar, Day Nicholas, Donnelly Peter, Chen Swaine, Salje Jeanne
Abstract excerpt
BACKGROUND: Orientia tsutsugamushi is a clinically important but neglected obligate intracellular bacterial pathogen of the Rickettsiaceae family that causes the potentially life-threatening human disease scrub typhus. In contrast to the genome reduction seen in many obligate intracellular bacteria, early genetic studies of Orientia have revealed one of the most repetitive bacterial genomes sequenced to date. The...
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