Article
Diversity of the 47-kD HtrA nucleic acid and translated amino acid sequences from 17 recent human isolates of Orientia.
Vector borne and zoonotic diseases (Larchmont, N.Y.) - 1 Jun 2013
Jiang Ju, Paris Daniel H, Blacksell Stuart D, Aukkanit Nuntipa, Newton Paul N, Phetsouvanh Rattanaphone, Izzard Leonard, Stenos John, Graves Stephen R, Day Nicholas P J, Richards Allen L
Abstract excerpt
Orientia tsutsugamushi, the etiologic agent of potentially fatal scrub typhus, is characterized by a high antigenic diversity, which complicates the development of a broadly protective vaccine. Efficacy studies in murine and nonhuman primate models demonstrated the DNA vaccine candidate pKarp47, based upon the O. tsutsugamushi Karp 47-kD HtrA protein gene, to be a successful immunoprophylactic against scrub...
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