Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Scarless genome editing: progress towards understanding genotype-phenotype relationships.

Current genetics - 1 Dec 2018

Elison Gregory L, Acar Murat

Abstract excerpt

The ability to predict phenotype from genotype has been an elusive goal for the biological sciences for several decades. Progress decoding genotype-phenotype relationships has been hampered by the challenge of introducing precise genetic changes to specific genomic locations. Here we provide a comparative review of the major techniques that have been historically used to make genetic changes in cells as well as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clustered Regularly Interspaced Short Palindromic Repeats
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Gene Editing

Share to Genetic Association Studies

Share to Genetic Engineering

Share to Genotype

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 29872908
DOI: 10.1007/s00294-018-0850-8
PMCID: PMC6281794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Scarless genome editing: progress towards understanding genotype-phenotype relationships.PMID 29872908Read ↗

Genotype to Phenotype: CRISPR Gene Editing Reveals Genetic Compensation as a Mechanism for Phenotypic Disjunction of Morphants and Mutants.Semantic proximity Read ↗

Genome Engineering at the Dawn of the Golden AgeSemantic proximity Read ↗

CRISPR Del/Rei: A simple, flexible, and efficient pipeline for scarless genome editingSemantic proximity Read ↗

Genetic engineering: Allele-specific genome editing of disease loci.Semantic proximity Read ↗

Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing.Semantic proximity Read ↗

Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking.Semantic proximity Read ↗

Precise and efficient scarless genome editing in stem cells using CORRECT.Semantic proximity Read ↗

Tools and strategies for scarless allele replacement in Drosophila using CRISPR/Cas9.Semantic proximity Read ↗

Research Techniques Made Simple: CRISPR Genetic Screens.Semantic proximity Read ↗

Editing the Genome Without Double-Stranded DNA BreaksSemantic proximity Read ↗

Comment: Genotype-phenotype correlation with CRISPR-Cas9-: Bedside to bench.Semantic proximity Read ↗

Use of genome-editing tools to treat sickle cell diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.