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Article

Mucosal associated invariant T cells are differentially impaired in tolerant and immunosuppressed liver transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Jan 2021

Sattler Arne, Thiel Lion G, Ruhm Annkathrin H, Bergmann Yasmin, Dornieden Theresa, Choi Mira, Halleck Fabian, Friedersdorff Frank, Eurich Dennis, Kotsch Katja

Abstract excerpt

Mucosal associated invariant T (MAIT-) cells represent a semi-invariant T cell population responsive to microbial vitamin B metabolite and innate cytokine stimulation, executing border tissue protection and particularly contributing to human liver immunity. The impact of immunosuppressants on MAIT cell biology alone and in context with solid organ transplantation has not been thoroughly examined. Here, we...

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PMID: 32515136
DOI: 10.1111/ajt.16122

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