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Article

Establishment of a congenital tooth agenesis related gene MSX1 knockout human embryonic stem cell lines by CRISPR-Cas9 technology.

Stem cell research - 1 Oct 2017

Xue Yanting, Zhu Minghui, Qin Dajiang, Li Yongjin, Cen Xiaotong, Sun Xiaofang, Lian Wenwei, Liao Baojian

Abstract excerpt

Human MSX1 gene is mapped to chromosome 4 and encodes a 303aa homeobox protein MSX1. MSX1 expression appears during early tooth development of vertebrate embryogenesis. Mutations in this protein are related to human tooth anomalie, cleft lip and palate and congenital ectodermal dysplasia syndrome. Most of the confirmed pathogenic mutations are located in exon2 encoded homeobox domain. Here, we report the...

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Identifiers

PMID: 29034883
DOI: 10.1016/j.scr.2017.05.008

Genes

MSX1

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