Article
Ruthenium‐Containing Linear Helicates and Mesocates with Tuneable p53‐Selective Cytotoxicity in Colorectal Cancer Cells
4 Jun 2018
Abstract excerpt
Abstract The ligands L 1 and L 2 both form separable dinuclear double‐stranded helicate and mesocate complexes with Ru II . In contrast to clinically approved platinates, the helicate isomer of [Ru 2 ( L 1 ) 2 ] 4+ was preferentially cytotoxic to isogenic cells (HCT116 p53 −/− ), which lack the critical tumour suppressor gene. The mesocate isomer shows the reverse selectivity, with the achiral isomer being...
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