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Article

A novel phenotype-based approach for systematically screening antiproliferation metallodrugs.

Chemico-biological interactions - 10 Nov 2009

Wang Yun-Hsin, Cheng Chien-Chung, Lee Wen-Jie, Chiou Min-Lun, Pai Chiung-Wen, Wen Chi-Chung, Chen Wei-Li, Chen Yau-Hung

Abstract excerpt

Ruthenium (Ru) derivatives have less toxicity and higher water-solubility than cisplatin, giving them great potential as antitumor metallodrugs. In this study, zebrafish were employed as a whole-organism model to screen new Ru compounds for anti-cell proliferation activity. After soaking fish embryos in cisplatin and five Ru derivatives, [Ru(terpy)(bpy)Cl]Cl, [Ru(terpy)(dppz)OH(2)](ClO(4))(2),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19682442
DOI: 10.1016/j.cbi.2009.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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