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Article

Epigenetic silencing of miR‐1271 enhances MEK1 and TEAD4 expression in gastric cancer

4 Jun 2018

Abstract excerpt

Epigenetic dysregulation is a major driver of tumorigenesis. To identify tumor-suppressive microRNAs repressed by DNA methylation in gastric cancer (GC), we analyzed the genome-wide DNA methylation and microRNA expression profiles of EpCAM+/CD44+ GC cells. Among the set of microRNAs screened, miR-1271 was identified as a microRNA repressed by DNA methylation in GC. Forced miR-1271 expression substantially...

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PMID: 29862663
DOI: 10.1002/cam4.1605

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