Article
Patients with Obesity Caused by Melanocortin-4 Receptor Mutations Can Be Treated with a Glucagon-like Peptide-1 Receptor Agonist.
Cell metabolism - 3 Jul 2018
Iepsen Eva W, Zhang Jinyi, Thomsen Henrik S, Hansen Elizaveta L, Hollensted Mette, Madsbad Sten, Hansen Torben, Holst Jens J, Holm Jens-Christian, Torekov Signe S
Abstract excerpt
Pathogenic mutations in the appetite-regulating melanocortin-4 receptor (MC4R) represent the most common cause of monogenic obesity with limited treatment options. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) cause weight loss by reducing appetite. We assessed the effect of the GLP-1 RA liraglutide 3.0 mg for 16 weeks in 14 obese individuals with pathogenic MC4R mutations (BMI 37.5 ± 6.8) and 28 matched...
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