Article
Commentary on "DNA damage response and repair gene alterations are associated with improved survival in patients with platinum-treated advanced urothelial carcinoma."
Urologic oncology - 1 Jul 2018
Teo M Y, Bambury R M, Zabor E C, Jordan E, Al-Ahmadie H, Boyd M E, Bouvier N, Mullane S A, Cha E K, Roper N, Ostrovnaya I, Hyman D M, Bochner B H, Arcila M E, Solit D B, Berger M F, Bajorin D F, Bellmunt J, Iyer G, Rosenberg J E
Abstract excerpt
PURPOSE: Platinum-based chemotherapy remains the standard treatment for advanced urothelial carcinoma by inducing DNA damage. We hypothesize that somatic alterations in DNA damage response and repair (DDR) genes are associated with improved sensitivity to platinum-based chemotherapy. EXPERIMENTAL DESIGN: Patients with diagnosis of locally advanced and metastatic urothelial carcinoma treated with platinum-based...
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